GFAP Alternative splicing and the relevance for disease–A focus on diffuse gliomas

JV van Asperen, PAJT Robe, EM Hol - ASN neuro, 2022 - journals.sagepub.com
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic
for astrocytes and neural stem cells, and their malignant analogues in glioma. Since the …

GFAPδ: A promising biomarker and therapeutic target in glioblastoma

R Radu, GED Petrescu, RM Gorgan… - Frontiers in oncology, 2022 - frontiersin.org
GFAPδ, the delta isoform of the glial fibrillary acidic protein, is mainly expressed in the
subventricular zone of the brain, together with other neural stem cell markers like nestin. The …

GFAP serves as a structural element of tunneling nanotubes between glioblastoma cells and could play a role in the intercellular transfer of mitochondria

L Simone, DL Capobianco, F Di Palma… - Frontiers in Cell and …, 2023 - frontiersin.org
Tunneling nanotubes (TNTs) are long F-actin-positive plasma membrane bridges
connecting distant cells, allowing the intercellular transfer of cellular cargoes, and are found …

Comprehensive analysis of prognostic tumor microenvironment-related genes in osteosarcoma patients

C Hu, C Liu, S Tian, Y Wang, R Shen, H Rao, J Li… - BMC cancer, 2020 - Springer
Background Tumor microenvironment (TME) plays an important role in malignant tumors.
Our study aimed to investigate the effect of the TME and related genes in osteosarcoma …

Ultra high-plex spatial proteogenomic investigation of giant cell glioblastoma multiforme immune infiltrates reveals distinct protein and RNA expression profiles

SA Bonnett, AB Rosenbloom, GT Ong, M Conner… - Cancer Research …, 2023 - AACR
A deeper understanding of complex biological processes, including tumor development and
immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we …

Quiescin sulfhydryl oxidase 1 regulates the proliferation, migration and invasion of human glioblastoma cells via PI3K/Akt pathway

Y Geng, C Xu, Y Wang, L Zhang - OncoTargets and therapy, 2020 - Taylor & Francis
Background Quiescin sulfhydryl oxidase 1 (QSOX1) involves in the formation of disulfide
bonds and participates in the protein folding process. In recent years, accumulating …

High VEGFA expression is associated with improved progression-free survival after bevacizumab treatment in recurrent glioblastoma

B Alves, J Peixoto, S Macedo, J Pinheiro, B Carvalho… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma (GB) is a deadly tumor that demands for relevant biomarkers,
particularly regarding patients' response to treatment. MMP-2, MMP-9, VEGFA, and YKL40 …

[HTML][HTML] TBK1 inhibitor exerts antiproliferative effect on glioblastoma multiforme cells

SA Scuderi, M Lanza, G Casili, F Esposito… - Oncology …, 2021 - ncbi.nlm.nih.gov
Glioma are common malignant brain tumors, among which glioblastoma multiforme (GBM)
has the worst prognosis. Different studies of GBM revealed that targeting nuclear factor κB …

Preoperative and early postoperative seizures in patients with glioblastoma—two sides of the same coin?

Y Ahmadipour, L Rauschenbach… - Neuro-oncology …, 2021 - academic.oup.com
Background Symptomatic epilepsy is a common symptom of glioblastoma, which may occur
in different stages of disease. There are discrepant reports on association between early …

Prognostic Factors of Survival in Glioblastoma Multiforme Patients—A Retrospective Study

G Șerban, F Tămaș, R Bălașa, D Manu, C Tămaș… - Diagnostics, 2022 - mdpi.com
Background: Glioblastoma multiforme (GBM) is the most aggressive brain tumor that occurs
in adults. In spite of prompt diagnosis and rapidly administered treatment, the survival …