Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …

Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role
in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was …

Direct visualization and light control of several cellular processes is a challenge, owing to
the spectral overlap of available genetically encoded probes. Here we report the most red …

Cell–cell fusion is a crucial and highly regulated event in the genesis of both form and
function of many tissues. One particular type of cell fusion, myoblast fusion, is a key cellular …

Low molecular weight G proteins of the Rho subfamily are regulators of actin cytoskeletal
organization. In contrast to the heterotrimeric G proteins, the small GTPases are not directly …

It is now well established that the small GTPases of the Rho family—Rac, Cdc42 and Rho—
regulate growth cone morphology. Less clear is their role in guiding the growth cone. Do …

The Rho-guanine nucleotide exchange factor (RhoGEF) TRIO acts as a key regulator of
neuronal migration, axonal outgrowth, axon guidance, and synaptogenesis by activating the …

Rho GTPases control actin reorganization and many other cellular functions. Guanine
nucleotide-exchange factors (GEFs) activate Rho GTPases by promoting their exchange of …