Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

[HTML][HTML] Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes

A Kaisanlahti, T Glumoff - Journal of physiology and biochemistry, 2019 - Springer
Mammalian adipose tissue is traditionally categorized into white and brown relating to their
function and morphology: while white serves as an energy storage, brown adipose tissue …

The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity

S Chen, X Liu, C Peng, C Tan, H Sun, H Liu, Y Zhang… - Cell Metabolism, 2021 - cell.com
Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the
treatment of obesity. However, pharmacologic engagement of this process has proven …

The role of thyroid hormone in metabolism and metabolic syndrome

PFS Teixeira, PB Dos Santos… - … in endocrinology and …, 2020 - journals.sagepub.com
Metabolic syndrome (MetS) and thyroid dysfunction are common in clinical practice. The
objectives of this review are to discuss some proposed mechanisms by which thyroid …

Brown and beige adipose tissue and aging

E Zoico, S Rubele, A De Caro, N Nori… - Frontiers in …, 2019 - frontiersin.org
Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes
dysfunctional with an increase in production of inflammatory peptides, a decline of those …

Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice

B Xia, XC Shi, BC Xie, MQ Zhu, Y Chen, XY Chu… - PLoS …, 2020 - journals.plos.org
Obesity leads to multiple health problems, including diabetes, fatty liver, and even cancer.
Here, we report that urolithin A (UA), a gut-microflora–derived metabolite of pomegranate …

The adipocyte supersystem of insulin and cAMP signaling

A Guilherme, LA Rowland, H Wang, MP Czech - Trends in cell biology, 2023 - cell.com
Adipose tissue signals to brain, liver, and muscles to control whole body metabolism through
secreted lipid and protein factors as well as neurotransmission, but the mechanisms …

Obesity: a neuroimmunometabolic perspective

CM Larabee, OC Neely, AI Domingos - Nature Reviews Endocrinology, 2020 - nature.com
Neuroimmunology and immunometabolism are burgeoning topics of study, but the
intersection of these two fields is scarcely considered. This interplay is particularly prevalent …

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications

Z Ghesmati, M Rashid, S Fayezi, F Gieseler… - Reviews in Endocrine …, 2024 - Springer
Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and
beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT …

Thermogenic adipose tissue in energy regulation and metabolic health

S Xue, D Lee, DC Berry - Frontiers in endocrinology, 2023 - frontiersin.org
The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …