Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous
epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) …

Bullous pemphigoid is the most frequent autoimmune bullous disease and mainly affects
elderly individuals. Increase in incidence rates in the past decades has been attributed to …

Rare diseases, an emerging global public health priority, require an evidence-based
estimate of the global point prevalence to inform public policy. We used the publicly …

Autoimmune bullous disorders are a heterogeneous spectrum of skin disorders
characterized by the production of autoantibodies against adhesion molecules of the skin …

This document provides a comprehensive summary of evidence on the current situation of
rare diseases (RDs) globally and regionally, including conditions, practices, policies, and …

Pemphigus diseases (PDs) and mucous membrane pemphigoid (MMP) are a group of
immune-mediated mucocutaneous disorders clinically characterized by the formation of …

Mesenchymal stem cells (MSCs) are a promising therapy for immune-mediated and
inflammatory disorders, because of their potent immunomodulatory properties. In this study …

Background Successful development of new treatments for rare diseases (RDs) and their
sustainable patient access require overcoming a series of challenges related to research …

Background Lipodystrophy (LD; non-human immunodeficiency virus [HIV]-associated)
syndromes are a rare body of disorders for which true prevalence is unknown. Prevalence …

Background Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly
affects older people. Although the disease is associated with considerable morbidity and …