Plasma proteomic associations with genetics and health in the UK Biobank

BB Sun, J Chiou, M Traylor, C Benner, YH Hsu… - Nature, 2023 - nature.com
Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium
characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we …

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

BB Sun, J Chiou, M Traylor, C Benner, YH Hsu… - BioRxiv, 2022 - biorxiv.org
Abstract The UK Biobank Pharma Proteomics Project (UKB-PPP) is a collaboration between
the UK Biobank (UKB) and thirteen biopharmaceutical companies characterising the plasma …

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

M Tamlander, N Mars, M Pirinen… - Communications …, 2022 - nature.com
Large-scale biobank initiatives and commercial repositories store genomic data collected
from millions of individuals, and tools to leverage the rapidly growing pool of health and …

Polygenic risk scores in coronary artery disease

MK Christiansen, M Nyegaard… - Current Opinion in …, 2023 - journals.lww.com
Polygenic risk scores in coronary artery disease : Current Opinion in Cardiology Polygenic risk
scores in coronary artery disease : Current Opinion in Cardiology Log in or Register Subscribe …

Artificial intelligence for risk assessment on primary prevention of coronary artery disease

SF Chen, S Loguercio, KY Chen, SE Lee… - Current Cardiovascular …, 2023 - Springer
Abstract Purpose of Review Coronary artery disease (CAD) is a common and etiologically
complex disease worldwide. Current guidelines for primary prevention, or the prevention of …

Combining polygenic and proteomic risk scores with clinical risk factors to improve performance for diagnosing absence of coronary artery disease in patients with de …

PL Møller, PD Rohde, JN Dahl… - Circulation: Genomic …, 2023 - Am Heart Assoc
Background: Patients with de novo chest pain, referred for evaluation of possible coronary
artery disease (CAD), frequently have an absence of CAD resulting in millions of tests not …

Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy

S Winther, LD Rasmussen, J Westra… - Open …, 2023 - openheart.bmj.com
Introduction Current guideline recommend functional imaging for myocardial ischaemia if
coronary CT angiography (CTA) has shown coronary artery disease (CAD) of uncertain …

A genome-wide genomic score added to standard recommended stratification tools does not improve the identification of patients with very low bone mineral density

J Therkildsen, PD Rohde, L Nissen, J Thygesen… - Osteoporosis …, 2023 - Springer
The role of integrating genomic scores (GSs) needs to be assessed. Adding a GS to
recommended stratification tools does not improve the prediction of very low bone mineral …

[HTML][HTML] Protocol: Danish study of Non-Invasive Testing in Coronary Artery Disease 3 (Dan-NICAD 3): study design of a controlled study on optimal diagnostic strategy

S Winther, LD Rasmussen, J Westra… - Open Heart, 2023 - ncbi.nlm.nih.gov
Introduction Current guideline recommend functional imaging for myocardial ischaemia if
coronary CT angiography (CTA) has shown coronary artery disease (CAD) of uncertain …

Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) …

JD Newman, PS Douglas, I Zhbannikov, M Ferencik… - American heart …, 2022 - Elsevier
A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD)
independent of traditional risk factors. Coronary computed tomography angiography (CTA) …