Mathematical models of biological systems need to both reflect and manage the inherent
complexities of biological phenomena. Through their versatility and ability to capture …

Increasingly-sophisticated parameter-sensitivity analysis techniques continue to be
developed, and each technique comes with its own set of advantages and disadvantages …

Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of
treatment resistant disease. Defining how, when and where myeloma cell intrinsic and …

As decisions in drug development increasingly rely on predictions from mechanistic systems
models, assessing the predictive capability of such models is becoming more important …

A mathematical model is formulated to delve into the changes that have been produced on
the natural interactive dynamics between plants and carbon dioxide when mining intervenes …

Bladder cancer is a common malignancy with over 80,000 estimated new cases and nearly
18,000 deaths per year in the United States alone. Therapeutic options for metastatic …

The release of tumor antigens during traditional cancer treatments (such as chemo-or
radiotherapy) can lead to a stimulation of the immune response which provides synergistic …

While many novel therapies have been approved in recent years for treating patients with
multiple myeloma, there is still no established curative regimen, especially for patients with …

Multiple myeloma (MM) is an osteolytic plasma cell malignancy that, despite being
responsive to therapies such as proteasome inhibitors, frequently relapses. Understanding …

Cancer metastasis accounts for a majority of cancer-related deaths worldwide. Metastasis
occurs when the primary tumor sheds cells into the blood and lymphatic circulation, thereby …