Microbiome and metabolome in inflammatory bowel disease

KG Upadhyay, DC Desai, TF Ashavaid… - Journal of …, 2023 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease of unknown etiology,
involving complex interactions between the gut microbiome and host immune response. The …

Novel fibro-inflammatory biomarkers associated with disease activity in patients with Crohn's disease

M Pehrsson, MS Alexdóttir, MA Karsdal… - Expert Review of …, 2023 - Taylor & Francis
Introduction Crohn's disease (CD) is a complex disease, and assessing activity is
challenging due to pathobiologic process eg ECM remodeling, mucosal damage, and …

Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism

T Liu, Z Ning, P Liu, H Gao - Frontiers in Immunology, 2023 - frontiersin.org
Ulcerative colitis (UC) is one form of inflammatory bowel disease (IBD), characterized by
chronic relapsing intestinal inflammation. As increasing morbidity of UC and deficiency of …

Bile acid alterations associated with indolent course of inflammatory bowel disease

C Liu, S Zhan, N Li, T Tu, J Lin, M Li… - Scandinavian Journal …, 2023 - Taylor & Francis
Background The indolent course of treatment-naive patients with inflammatory bowel
disease (IBD) is confirmed predictable based on clinical characteristics. Current evidences …

[HTML][HTML] Multi-omics in Crohn's disease: New insights from inside

C Mu, Q Zhao, Q Zhao, L Yang, X Pang, T Liu… - Computational and …, 2023 - Elsevier
Crohn's disease (CD) is an inflammatory bowel disease (IBD) with complex clinical
manifestations such as chronic diarrhea, weight loss and hematochezia. Despite the …

Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases

AV Vila, J Zhang, M Liu, KN Faber, RK Weersma - Gut, 2024 - gut.bmj.com
The gut microbiome has been recognised as a key component in the pathogenesis of
inflammatory bowel diseases (IBD), and the wide range of metabolites produced by gut …

Dynamic alterations in metabolomics and transcriptomics associated with intestinal fibrosis in a 2, 4, 6-trinitrobenzene sulfonic acid-induced murine model

J Wu, Z Tian, X Zhuang, Y Chen, T Fan, J Li… - Journal of Translational …, 2023 - Springer
Background & aims Intestinal fibrosis is a common and severe complication of inflammatory
bowel disease without clear pathogenesis. Abnormal expression of host genes and …

Ion Mobility Spectrometry for the Metabolomic Study of Inflammatory Bowel Disease Using the Volatile Organic Compounds Profile in Human Serum and Urine

M García-Nicolás, MC Pérez-Álvarez… - Chemosensors, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is an immune-mediated disease characterized by chronic
mucosal inflammation of the digestive tract. The IBD diagnosis is currently based on the …

Gas chromatography-mass spectrometry-based metabolomics reveals the potential mechanism of action of saikosaponin D against DSS-induced acute ulcerative …

Y Yan, S Yin, X Bian, J Li, P Wei, X Guo, J Zhou… - Phytochemistry …, 2023 - Elsevier
Ulcerative colitis (UC) is a part of the cluster of conditions–known as inflammatory bowel
disease. It is caused by a plethora of factors that on a long-term basis result in inflammation …

Alterations in Blood Plasma Metabolome of Patients with Lesniowski-Crohn's Disease Shortly after Surgical Treatment—Pilot Study

J Idkowiak, G Kubiak-Tomaszewska, P Gątarek… - Metabolites, 2022 - mdpi.com
Lesniowski-Crohn's disease (CD) is a type of chronic inflammatory bowel disease (IBD) of
uncertain etiology. Initially, pharmacological management is undertaken; however, surgical …