Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive
species are reviewed. A short introduction summarizes the basic reactivities of aryne …

Catalysis is becoming a strategic field of science because it represents a new way to meet
the challenges of energy and sustainability. These challenges are becoming the main …

1. INTRODUCTION Within 14 years of the seminal experiments of JD Roberts leading to the
first proposal of the structure of benzyne (1), 1 synthetic organic chemists recognized the …

In studying the evolution of organic chemistry and grasping its essence, one comes quickly
to the conclusion that no other type of reaction plays as large a role in shaping this domain …

Abstract The Diels–Alder reaction has both enabled and shaped the art and science of total
synthesis over the last few decades to an extent which, arguably, has yet to be eclipsed by …

Collectively, palladium‐catalyzed coupling reactions represent some of the most powerful
and versatile tools available to synthetic organic chemists. Their widespread popularity …

The design and implementation of cascade reactions is a challenging facet of organic
chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic …

This Minireview highlights recent advances in the field of aryne and cyclohexyne chemistry
that have allowed the extraordinary reactivity of these entities to be harnessed during the …

This Account provides an overview and examples of function-oriented synthesis (FOS) and
its increasingly important role in producing therapeutic leads that can be made in a step …