Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: an international expert opinion on the available evidence and …
RS McIntyre, JD Rosenblat… - American Journal of …, 2021 - Am Psychiatric Assoc
Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …
with major depressive disorder. Despite the proven efficacy of monoamine-based …
Prefrontal cortex and depression
DA Pizzagalli, AC Roberts - Neuropsychopharmacology, 2022 - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
New and emerging approaches to treat psychiatric disorders
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …
the lives of millions of people worldwide. Although their etiological and diagnostic …
Toward a better understanding of the mechanisms and pathophysiology of anhedonia: are we ready for translation?
DA Pizzagalli - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
[HTML][HTML] Advances in resting state fMRI acquisitions for functional connectomics
Resting state functional magnetic resonance imaging (rs-fMRI) is based on spontaneous
fluctuations in the blood oxygen level dependent (BOLD) signal, which occur simultaneously …
fluctuations in the blood oxygen level dependent (BOLD) signal, which occur simultaneously …
Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
S Wang, F Leri, SJ Rizvi - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms
S Kohtala - Pharmacological Reports, 2021 - Springer
Over the past 50 years, ketamine has solidified its position in both human and veterinary
medicine as an important anesthetic with many uses. More recently, ketamine has been …
medicine as an important anesthetic with many uses. More recently, ketamine has been …
S-ketamine as an adjuvant in patient-controlled intravenous analgesia for preventing postpartum depression: a randomized controlled trial
Background Postpartum depression (PPD) is a common complication of cesarean section. S-
ketamine given intravenously during surgery can help prevent PPD. However, whether S …
ketamine given intravenously during surgery can help prevent PPD. However, whether S …
Functional contribution of the medial prefrontal circuitry in major depressive disorder and stress-induced depressive-like behaviors
Despite decades of research on the neurobiology of major depressive disorder (MDD), the
mechanisms underlying its expression remain unknown. The medial prefrontal cortex …
mechanisms underlying its expression remain unknown. The medial prefrontal cortex …
The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion
Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …