Arachidonic acid can be oxygenated by a variety of different enzymes, including
lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …

This review of leukotrienes, which are lipid mediators with a broad array of clinical effects,
and leukotriene receptors considers the biochemical and physiological aspects of these …

Glucose, as the main consuming nutrient of the body, faces different destinies in cancer
cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce …

5-Lipoxygenase (5-LO) catalyzes the conversion of arachidonic acid (AA) into leukotriene
(LT) A4 and 5-hydroperoxyeicosatetraenoic acid. LTA4 can then be converted into LTB4 by …

The Influenza A virus (IAV) is a major human pathogen that produces significant morbidity
and mortality. To explore the contribution of alveolar macrophages (AlvMΦs) in regulating …

Extensive studies have implicated the role of dietary fatty acids in prostatecancer
progression. Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growth …

Leukotrienes are biologically active eicosanoid lipid mediators that originate from oxidative
metabolism of arachidonic acid. Biosynthesis of leukotrienes involves a set of soluble and …

Cyclooxygenase (COX) and lipoxygenase (LO) metabolic pathways are emerging as key
regulators of cell proliferation and neo‐angiogenesis. COX and LO inhibitors are being …

Arachidonic acid (AA) and its metabolites have recently generated a heightened interest due
to growing evidence of their significant role in cancer biology. Thus, inhibitors of the AA …

The biosynthesis of leukotrienes (LTs) is initiated by the transformation of free arachidonic
acid to LTA 4 by 5-lipoxygenase (5-LO). Subsequent enzymatic conversion of LTA 4 yields …