Regulation of the mitochondrial reactive oxygen species: Strategies to control mesenchymal stem cell fates ex vivo and in vivo

C Hu, L Zhao, C Peng, L Li - Journal of cellular and molecular …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSC s) are broadly used in cell‐based regenerative medicine
because of their self‐renewal and multilineage potencies in vitro and in vivo. To ensure …

Cell sources for articular cartilage repair strategies: shifting from monocultures to cocultures

JCH Leijten, N Georgi, L Wu… - … Engineering Part B …, 2013 - liebertpub.com
The repair of articular cartilage is challenging due to the sparse native cell population
combined with the avascular and aneural nature of the tissue. In recent years, cartilage …

Small molecule mesengenic induction of human induced pluripotent stem cells to generate mesenchymal stem/stromal cells

YS Chen, RA Pelekanos, RL Ellis… - Stem cells …, 2012 - academic.oup.com
The translational potential of mesenchymal stem/stromal cells (MSCs) is limited by their
rarity in somatic organs, heterogeneity, and need for harvest by invasive procedures …

Human adipose-derived stromal cells in a clinically applicable injectable alginate hydrogel: phenotypic and immunomodulatory evaluation

B Follin, M Juhl, S Cohen, AE Pedersen, M Gad… - Cytotherapy, 2015 - Elsevier
Background aims Clinical trials have documented beneficial effects of mesenchymal stromal
cells from bone marrow and adipose tissue (ASCs) as treatment in patients with ischemic …

A robust and reproducible animal serum-free culture method for clinical-grade bone marrow-derived mesenchymal stromal cells

A Laitinen, S Oja, L Kilpinen, T Kaartinen, J Möller… - Cytotechnology, 2016 - Springer
Efficient xenofree expansion methods to replace fetal bovine serum (FBS)-based culture
methods are strongly encouraged by the regulators and are needed to facilitate the adoption …

Optimization and scale-up culture of human endometrial multipotent mesenchymal stromal cells: potential for clinical application

G Rajaraman, J White, KS Tan, D Ulrich… - … Engineering Part C …, 2013 - liebertpub.com
We have previously identified and purified multipotent mesenchymal stromal cell (MSC)-like
cells in the highly regenerative endometrial lining of the human uterus (eMSC) as CD140b+ …

Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I

TA Karlsen, JE Brinchmann - Molecular Therapy, 2013 - cell.com
Synthetic microRNAs regulate gene expression when transfected into cells, and may be
used in strategies for molecular therapy both in vitro and in vivo. Liposomal transfection …

Genetic engineering of mesenchymal stem cells by non-viral gene delivery

W Wang, X Xu, Z Li, A Lendlein… - Clinical hemorheology …, 2014 - content.iospress.com
Mesenchymal stem cells (MSCs) are an ideal cell source for tissue engineering and
regenerative medicine as they possess self-renewal properties and multilineage …

Oxygenated environment enhances both stem cell survival and osteogenic differentiation

S Benjamin, D Sheyn, S Ben-David, A Oh… - … Engineering Part A, 2013 - liebertpub.com
Osteogenesis of mesenchymal stem cells (MSCs) is highly dependent on oxygen supply.
We have shown that perfluorotributylamine (PFTBA), a synthetic oxygen carrier, enhances …

Neuro-differentiated Ntera2 cancer stem cells encapsulated in alginate beads: First evidence of biological functionality

I Cacciotti, C Ceci, A Bianco, G Pistritto - Materials Science and …, 2017 - Elsevier
The present communication investigates an application of alginate encapsulation
technology to the differentiation of the embryonic cancer stem NTera2 cells (NT2) into …