Drug resistance has compromised the efficacy of chemotherapy. The dysregulation of drug
transporters including P-glycoprotein (P-gp) can mediate drug resistance through drug …

Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A
mechanism underlying MDR is the overexpression of efflux transporters associated with …

SET (Suppressor of variegation, Enhancer of Zeste, Trithorax) and MYND (Myeloid-Nervy-
DEAF1) domain-containing protein 2 (SMYD2) is a protein methyltransferase that methylates …

The protein methyltransferase SET and MYND domain-containing protein 2 (SMYD2) is a
transcriptional regulator that methylates histones and nonhistone proteins. As an oncogene …

SMYD2 is a histone methyltransferase, which methylates both histone H3K4 as well as a
number of non-histone proteins. Dysregulation of SMYD2 has been associated with several …

A major cause of oxaliplatin chemoresistance in colorectal cancer (CRC) is acquired
epithelial-mesenchymal transition (EMT) in cancer cells, making the cancer cells easy to …

Background Epigenetic modifiers, such as methyltransferases, play crucial roles in the
regulation of many biological processes, including development, cancer and multiple …

Simple Summary Epigenetic modifications can regulate gene expression by altering
chromatin structure. Since the beginning of comprehensive research into changes in gene …

A comprehensive understanding of the mechanisms involved in epigenetic changes in gene
expression is essential to the clinical management of diseases linked to the SMYD family of …

Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies
worldwide and has high morbidity and mortality. Elucidating the molecular mechanisms …