There is increasing recognition that systematic post–cardiac arrest care after return of
spontaneous circulation (ROSC) can improve the likelihood of patient survival with good …

Cooling can reduce primary injury and prevent secondary injury to the brain after insults in
certain clinical settings and in animal models of brain insult. The mechanisms that underlie …

Background Cardiac arrest outside the hospital is common and has a poor outcome. Studies
in laboratory animals suggest that hypothermia induced shortly after the restoration of …

Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Background Cardiac arrest with widespread cerebral ischemia frequently leads to severe
neurologic impairment. We studied whether mild systemic hypothermia increases the rate of …

Background Cerebral hypothermia can improve outcome of experimental perinatal hypoxia-
ischaemia. We did a multicentre randomised controlled trial to find out if delayed head …

Neuroprotection for ischemic stroke refers to strategies, applied singly or in combination, that
antagonize the injurious biochemical and molecular events that eventuate in irreversible …

Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

Therapeutic hypothermia, or cooling of the body or brain for the purposes of preserving
organ viability, is one of the most robust neuroprotectants at both the preclinical and clinical …

Objective Hypothermia has been used for medicinal purposes since ancient times. This
paper reviews the current potential clinical applications for mild hypothermia (32–35° C) …