Iron is abundantly present on earth, essential for most microorganisms and crucial for
human health. Human iron deficiency that is nevertheless highly prevalent in developing …

By virtue of its unique electrochemical properties, iron makes an ideal redox active cofactor
for many biologic processes. In addition to its important role in respiration, central …

Environmental H2O2 creates several injuries in Escherichia coli, including the oxidative
conversion of dehydratase [4Fe–4S] clusters to an inactive [3Fe–4S] form. To protect itself …

The tricarboxylic acid (TCA) cycle plays two essential roles in metabolism. First, under
aerobic conditions the cycle is responsible for the total oxidation of acetyl-CoA that is …

Escherichia coli is a metabolically versatile bacterium that is able to grow in the presence
and absence of oxygen. Several previous transcript-profiling experiments have compared …

All regulatory processes require components that sense the environmental or metabolic
conditions of the cell, and sophisticated sensory proteins have been studied in great detail …

Significance: In recent years, bacterial iron–sulfur cluster proteins that function as regulators
of gene transcription have emerged as a major new group. In all cases, the cluster acts as a …

Bacteria have evolved complex sensing and signaling systems to react to their changing
environments, most of which are present in all domains of life. Canonical bacterial sensing …

Synechocystis sp. PCC 6803 is a widely used model cyanobacterium whose genome has
been well annotated. However, several additional small protein coding sequences (sORFs) …

As for all other organisms, life of bacterial pathogens has been subject to a selective
pressure to grow and multiply. For these bacteria, the host is a huge source of nutrients, and …