While modernization has dramatically increased lifespan, it has also witnessed the nature of
stress has changed dramatically. Chronic stress result failures of homeostasis and thus lead …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Inflammation and lipid signaling are intertwined modulators of homeostasis and immunity. In
addition to the extensively studied eicosanoids and inositol phospholipids, emerging studies …

Approximately half of all deaths from liver cirrhosis, the tenth leading cause of mortality in the
United States, are related to alcohol use. Chronic alcohol consumption is accompanied by …

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient with no history of alcohol abuse or other causes for secondary hepatic …

Emerging data have shown a close association between compositional changes in gut
microbiota and the development of nonalcoholic fatty liver disease (NAFLD). The change in …

Inflammatory cell infiltration in the liver is a hallmark of nonalcoholic steatohepatitis (NASH).
The chemokine-chemokine receptor interaction induces inflammatory cell recruitment. CC …

The circadian clock controls metabolic and physiological processes through finely tuned
molecular mechanisms. The clock is remarkably plastic and adapts to exogenous" …

Kupffer cells have been implicated in the pathogenesis of various liver diseases. However,
their involvement in metabolic disorders of the liver, including fatty liver disease, remains …

Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical
presentations that can escalate to acute liver failure. The worldwide increase in the use of …