Advances in bioreactor control for production of biotherapeutic products

S Nikita, S Mishra, K Gupta, V Runkana… - Biotechnology and …, 2023 - Wiley Online Library
Advanced control strategies are well established in chemical, pharmaceutical, and food
processing industries. Over the past decade, the application of these strategies is being …

[HTML][HTML] Digitally enabled approaches for the scale up of mammalian cell bioreactors

MK Alavijeh, I Baker, YY Lee, SL Gras - Digital Chemical Engineering, 2022 - Elsevier
With recent advances in digitisation and big data analytics, more pharmaceutical firms are
adopting digital tools to achieve modernisation. The biological phenomena within …

Deep learning in preclinical antibody drug discovery and development

Y Zhou, Z Huang, W Li, J Wei, Q Jiang, W Yang… - Methods, 2023 - Elsevier
Antibody drugs have become a key part of biotherapeutics. Patients suffering from various
diseases have benefited from antibody therapies. However, its development process is …

Impact of mAb aggregation on its biological activity: rituximab as a case study

R Bansal, R Dash, AS Rathore - Journal of Pharmaceutical Sciences, 2020 - Elsevier
Monoclonal antibody (mAb) products are presently the dominant class of therapeutic
proteins. When stressed, they are known to be prone to molecular instabilities like …

[PDF][PDF] Digital Chemical Engineering

MK Alavijeh, I Baker, YY Lee, SL Gras - minerva-access.unimelb.edu.au
abstract With recent advances in digitisation and big data analytics, more pharmaceutical
firms are adopting digital tools to achieve modernisation. The biological phenomena within …