Natural products derived steroids as potential anti-leishmanial agents; disease prevalence, underlying mechanisms and future perspectives

MA Elawad, MEM Elkhalifa, AAE Hamdoon, LHM Salim… - Steroids, 2023 - Elsevier
Leishmaniasis is a vector-borne infection caused by protozoan parasites from the genus
leishmania and is among the most neglected tropical diseases. It is highly prevalent …

[HTML][HTML] Effects of terpenes in the treatment of visceral leishmaniasis: A systematic review of preclinical evidence

VD Raimundo, RPR Carvalho… - Pharmacological …, 2022 - Elsevier
Visceral leishmaniasis (VL) is a severe and potentially fatal neglected tropical disease,
being considered a public health concern in many countries worldwide. There are still no …

The golden touch by light: A finely engineered luminogen empowering high photoactivatable and photodynamic efficiency for cancer phototheranostics

X Chen, N Niu, D Li, Z Zhang, Z Zhuang… - Advanced Functional …, 2023 - Wiley Online Library
Photoactivatable agent is a powerful tool in biomedicine studies due to high‐precision
spatiotemporal control of light. However, those previously reported agents generally suffer …

α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway

M Hasanain, A Bhattacharjee, P Pandey, R Ashraf… - Cell Death & …, 2015 - nature.com
Abstract α-Solanine is a glycoalkaloid found in species of the nightshade family including
potato. It was primarily reported to have toxic effects in humans. However, there is a growing …

Apoptosis-like cell death in Leishmania donovani treated with KalsomeTM10, a new liposomal amphotericin B

M Shadab, B Jha, M Asad, M Deepthi, M Kamran, N Ali - PloS one, 2017 - journals.plos.org
Objective The present study aimed to elucidate the cell death mechanism in Leishmania
donovani upon treatment with KalsomeTM10, a new liposomal amphotericin B …

Light-triggered selective ROS-dependent autophagy by bioactive nanoliposomes for efficient cancer theranostics

T Appidi, DB Pemmaraju, RA Khan, SB Alvi… - Nanoscale, 2020 - pubs.rsc.org
Light-responsive nanoliposomes are being reported to induce cancer cell death through
heat and reactive oxygen species (ROS). Nanoliposomes (CIR NLPs) encapsulating a near …

Bioassay-based Corchorus capsularis L. leaf-derived β-sitosterol exerts antileishmanial effects against Leishmania donovani by targeting trypanothione reductase

PK Pramanik, S Chakraborti, A Bagchi… - Scientific Reports, 2020 - nature.com
Leishmaniasis, a major neglected tropical disease, affects millions of individuals worldwide.
Among the various clinical forms, visceral leishmaniasis (VL) is the deadliest. Current …

Synthesis, biological evaluation, structure–activity relationship, and mechanism of action studies of quinoline–metronidazole derivatives against experimental visceral …

A Upadhyay, P Chandrakar, S Gupta… - Journal of Medicinal …, 2019 - ACS Publications
In our efforts to identify novel chemical scaffolds for the development of antileishmanial
agents, a series of quinoline–metronidazole hybrid compounds was synthesized and tested …

Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil

S Hajaji, I Sifaoui, A López-Arencibia… - Parasitology …, 2018 - Springer
Abstract According to the World Health Organization, leishmaniasis is considered as a major
neglected tropical disease causing an enormous impact on global public health. Available …

Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and …

D Pratap Verma, MM Ansari, NK Verma… - Journal of Medicinal …, 2021 - ACS Publications
To design novel antimicrobial peptides by utilizing the sequence of the human host defense
protein, chemerin, a seven-residue amphipathic stretch located in the amino acid region …