Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

Twenty years ago, a number of eminent pharmaceutical scientists collaborated on an article
describing a rational approach to developing stable lyophilized protein formulations …

In ultrafiltration (UF) applications, the antifouling modification of semi-crystalline poly
(vinylidene fluoride)(PVDF) membrane aroused extensive attention. However, efforts have …

Increasing pressures on biomanufacturing costs have led to renewed interest in the
development of single-use technologies that can be readily adapted to continuous …

Ultrafiltration (UF) is used for the final concentration and formulation of essentially all
antibody‐based therapeutics including both monoclonal antibodies (mAbs) and Fc‐fusion …

Gas permeance of thin film composite (TFC) membranes may be restricted by the porosity
and pore size of microporous supports, resulting in a reduction in permeance. This work …

Highlights•Overview of intermolecular interactions in concentrated protein
formulations.•Second virial coefficient correlated with crystallization, aggregation, and …

Tangential flow filtration (TFF) through a 30 kDa nominal molecular weight cut‐off (MWCO)
ultrafiltration membrane is widely employed to concentrate purified monoclonal antibodies …

Buffer exchange, desalting, and formulation of high‐value biotherapeutics are currently
performed using batch diafiltration (DF); however, this type of tangential flow filtration …

As the use of biocatalyst proliferates due to the need for chirally pure active pharmaceutical
ingredients (API), the corresponding separation of biocatalyst and API is crucial. Although …