Hirsutine, an emerging natural product with promising therapeutic benefits: a systematic review

MS Bhuia, P Wilairatana, J Ferdous, R Chowdhury… - Molecules, 2023 - mdpi.com
Fruits and vegetables are used not only for nutritional purposes but also as therapeutics to
treat various diseases and ailments. These food items are prominent sources of …

Plant alkaloids as drug leads for Alzheimer's disease

YP Ng, TCT Or, NY Ip - Neurochemistry international, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative illness associated with dementia and is
most prevalent among the elderly population. Current medications can only treat symptoms …

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

Q Zhang, JJ Zhao, J Xu, F Feng, W Qu - Journal of Ethnopharmacology, 2015 - Elsevier
Abstract Ethnopharmacological relevance The genus Uncaria belongs to the family
Rubiaceae, which mainly distributed in tropical regions, such as Southeast Asia, Africa and …

Recent research progress of Uncaria spp. based on alkaloids: phytochemistry, pharmacology and structural chemistry

N Qin, X Lu, Y Liu, Y Qiao, W Qu, F Feng… - European Journal of …, 2021 - Elsevier
Medicinal plants are well-known in affording clinically useful agents, with rich medicinal
values by combining with disease targets through various mechanisms. Plant secondary …

Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity

J Zhou, S Zhou - Journal of Ethnopharmacology, 2010 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Uncaria species (Gouteng in Chinese) have
been used as ethnopharmacological medicines to treat ailments of the cardiovascular and …

Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases

JY Zhou, SW Zhou - Fitoterapia, 2012 - Elsevier
Uncaria species (Gouteng in Chinese) have been used as a plant medicine to treat ailments
of cardiovascular and central nervous systems. As the main alkaloid constituent of Uncaria …

Vasodilator compounds derived from plants and their mechanisms of action

FJ Luna-Vázquez, C Ibarra-Alvarado, A Rojas-Molina… - Molecules, 2013 - mdpi.com
The present paper reviews vasodilator compounds isolated from plants that were reported in
the past 22 years (1990 to 2012) and the different mechanisms of action involved in their …

Alkaloids extracted from Uncaria rhynchophylla demonstrate neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the PI3K/Akt/mTOR …

M Zheng, M Chen, C Liu, Y Fan, D Shi - Journal of ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Alkaloids isolated from Uncaria rhynchophylla (Miq.) Miq.
ex Havil.(Rubiaceae), alkaloids (URA) have been used to treat diseases related to the …

An updated review on the antimicrobial and pharmacological properties of Uncaria (Rubiaceae)

R Abdul, MR Wang, CJ Zhong, YY Liu, W Hou… - Journal of Herbal …, 2022 - Elsevier
Introduction Rapidly emerging diseases, such as viral infections, cancer, and autoimmune
disorders are becoming an increasing global health concern. Natural products, including …

Alkaloids from the Leaves of Uncaria rhynchophylla and Their Inhibitory Activity on NO Production in Lipopolysaccharide-Activated Microglia

D Yuan, B Ma, C Wu, J Yang, L Zhang… - Journal of Natural …, 2008 - ACS Publications
Two new isomeric alkaloids, 18, 19-dehydrocorynoxinic acid B (1) and 18, 19-
dehydrocorynoxinic acid (2), were isolated from the CHCl3 extract of the leaves of Uncaria …