In recent years, the importance of the gut microbiota in human health has been revealed and
many publications have highlighted its role as a key component of human physiology …

A growing body of documents shows microbiota produce metabolites such as short-chain
fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The accumulating evidence revealed that microbiota plays a significant function in training,
function, and the induction of host immunity. Once this interaction (immune system …

Sodium transport through various nephron segments is quite important in regulating sodium
reabsorption and blood pressure. Among several regulators of this process, insulin acts on …

Tightly coupled exchange of Na+ for H+ occurs across the surface membrane of virtually all
living cells. For years, the underlying molecular entity was unknown and the full …

The protein dipeptidyl peptidase 4 (DPP4) is a target in diabetes management and reduction
of associated cardiovascular risk. Inhibition of the enzymatic function and genetic deletion of …

Survival and proliferation signals are two processes closely interrelated and finely controlled
in most cell types, whose deregulation may lead to carcinogenesis. In the last decade …

Abstract The Slc9 family of Na+/H+ exchangers (NHEs) plays a critical role in electroneutral
exchange of Na+ and H+ in the mammalian intestine as well as other absorptive and …

The five plasma membrane Na+/H+ exchanger (NHE) isoforms in the gastrointestinal tract
are characterized by distinct cellular localization, tissue distribution, inhibitor sensitivities …