More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression
of metastatic cancer at distant sites that are not irradiated was described and called the …

Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …

The clinical utility of stimulator of interferon genes (STING) agonists has been limited due to
poor tumour-targeting and unwanted toxicity following systemic delivery. Here we describe a …

Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers,
but how tumor-infiltrating T cells are activated remains unclear. In this study, we explore the …

Successful combinations of radiotherapy and immunotherapy depend on the presence of
live T cells within the tumor; however, radiotherapy is believed to damage T cells. Here …

Purpose: In the proper context, radiotherapy can promote antitumor immunity. It is unknown
if elective nodal irradiation (ENI), a strategy that irradiates tumor-associated draining lymph …

Immunotherapies are the most rapidly growing drug class and have a major impact in
oncology and on human health. It is increasingly clear that the effectiveness of …

Radiotherapy (RT) is currently used in more than 50% of cancer patients during the course
of their disease in the curative, adjuvant or palliative setting. RT achieves good local control …

In the era of cancer immunotherapy, there is significant interest in combining conventional
cancer therapies, such as radiotherapy, with drugs that stimulate the immune system. The …

Pancreatic ductal adenocarcinoma (PDA), the most frequent type of pancreatic cancer,
remains one of the most challenging problems for the biomedical and clinical fields, with …