Mechanisms of bone development and repair

A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Materials design for bone-tissue engineering

GL Koons, M Diba, AG Mikos - Nature Reviews Materials, 2020 - nature.com
Successful materials design for bone-tissue engineering requires an understanding of the
composition and structure of native bone tissue, as well as appropriate selection of …

[HTML][HTML] Schwann cell functions in peripheral nerve development and repair

M Bosch-Queralt, R Fledrich, RM Stassart - Neurobiology of disease, 2023 - Elsevier
The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge

Q Min, DB Parkinson, XP Dun - Glia, 2021 - Wiley Online Library
Schwann cells within the peripheral nervous system possess a remarkable regenerative
potential. Current research shows that peripheral nerve‐associated Schwann cells possess …

[HTML][HTML] A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation …

Z Hao, L Ren, Z Zhang, Z Yang, S Wu, G Liu, B Cheng… - Bioactive materials, 2023 - Elsevier
Recent evidence highlights multifaceted biological needs to recapitulate the bone
microenvironment for bone regeneration. Neurotization has great potential for realizing multi …

Photosensitive and conductive hydrogel induced innerved bone regeneration for infected bone defect repair

X Jing, C Xu, W Su, Q Ding, B Ye, Y Su… - Advanced …, 2023 - Wiley Online Library
Repairing infected bone defects is a challenge in the field of orthopedics because of the
limited self‐healing capacity of bone tissue and the susceptibility of refractory materials to …

Hallmarks of peripheral nerve function in bone regeneration

R Tao, B Mi, Y Hu, S Lin, Y Xiong, X Lu, AC Panayi… - Bone research, 2023 - nature.com
Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

Crosstalk between bone and nerves within bone

QQ Wan, WP Qin, YX Ma, MJ Shen, J Li… - Advanced …, 2021 - Wiley Online Library
For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies

RM Stassart, JA Gomez-Sanchez… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges

W Sun, B Ye, S Chen, L Zeng, H Lu, Y Wan, Q Gao… - Bone Research, 2023 - nature.com
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …