The placenta is the chief regulator of nutrient supply to the growing embryo during gestation.
As such, adequate placental function is instrumental for developmental progression …

Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic
tissues, including the placenta. It consists of a spherical thin-walled layer, known as the …

INTRODUCTION The remarkable development of a single cell, the zygote, into the full
organism occurs through a complex series of division and differentiation events that …

Mammalian blastocysts comprise three distinct cell lineages essential for development
beyond implantation: the pluripotent epiblast, which generates the future embryo, and …

Treating pregnancy-related disorders is exceptionally challenging because the threat of
maternal and/or fetal toxicity discourages the use of existing medications and hinders new …

The placenta sits at the interface between the maternal and fetal vascular beds where it
mediates nutrient and waste exchange to enable in utero existence. Placental cells …

Maternal-offspring interactions in mammals involve both cooperation and conflict. The fetus
has evolved ways to manipulate maternal physiology to enhance placental nutrient transfer …

The placenta is the interface between mother and fetus in all eutherian species. However,
our understanding of this essential organ remains incomplete. A substantial challenge has …

The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …