Invasive fungal diseases (IFDs) have become major causes of morbidity and mortality
among highly immunocompromised patients. Authoritative consensus criteria to diagnose …

The progression of fibrosis in chronic hepatitis C determines the ultimate prognosis and thus
the need and urgency of therapy. Fibrogenesis is a complex dynamic process, which is …

An important feature of viruses with an RNA genome or that use RNA molecules as
intermediates of replication is their genetic variability, mainly resulting from the low fidelity of …

The hepatitis C virus (HCV) is the leading cause of chronic liver disease worldwide. It is
estimated that about 170 million people are chronically infected with HCV. Chronic hepatitis …

Hepatitis C virus (HCV) is a major cause of morbidity and mortality worldwide. The infection
becomes chronic in about 85% of infected individuals, in the face of a strong humoral and …

Background & Aims: Pegylated interferons (IFNs) with or without ribavirin were shown in
several studies to improve sustained virologic response compared with standard IFN α-2 …

Chronic hepatitis C virus (HCV) infection affects more than 170 million persons worldwide
and is responsible for the development of liver cirrhosis in many cases. Standard treatment …

Genetic heterogeneity is a hallmark of the hepatitis C virus, as a result largely of the infidelity
of viral RNA–dependent RNA polymerase. Random nucleotide substitutions are introduced …

Failure of interferon‐α (IFN‐α) treatment in patients with chronic hepatitis C virus (HCV)
infection is a challenging obstacle for clinical and experimental hepatology. Both viral and …

Hepatitis C virus (HCV) is a hepatotropic RNA virus with an extraordinary propensity to
persist in the vast majority of infected individuals. During replication, because of the inherent …