Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

The linker histone H1 family members are a key component of chromatin and bind to the
nucleosomal core particle around the DNA entry and exit sites. H1 can stabilize both …

The transcription factor STAT3 has a protective function in the heart. Until recently, the role of
STAT3 in hypertension-induced cardiac hypertrophy was unsettled. Earlier studies revealed …

Spin-Coupled Generalized Valence Bond (SCGVB) theory provides the foundation for a
comprehensive theory of the electronic structure of molecules. SCGVB theory offers a …

The transcription factor, signal transducer and activator of transcription 3 (STAT3), has been
implicated in protecting the heart from acute ischemic injury under both basal conditions and …

Aberrant activation of the JAK3-STAT signaling pathway is a characteristic feature of many
hematological malignancies. In particular, hyperactivity of this cascade has been observed …

The tetrahedron is the primary structural motif among the p-block elements and determines
the architecture of our bio-and geosphere. However, a broad understanding of the …

Abstract Background Aberrant JAK/STAT activation has been detected in many types of
human cancers. The role of JAK/STAT activation in cancer has been mostly attributed to …

Epithelial tissues rely on the adhesion between participating cells to retain their integrity.
The transmembrane protein E-cadherin is the major protein that mediates homophilic …