Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2, 4-dione derivatives: histone deacetylases inhibitory activity and molecular …
The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2, 4-dione derivatives
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
Development of new thiazolidine-2, 4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological …
This research study describes the development of new small molecules based on 2, 4-
thiazolidinedione (2, 4-TZD) and their aldose reductase (AR) inhibitory activities. The …
thiazolidinedione (2, 4-TZD) and their aldose reductase (AR) inhibitory activities. The …
[HTML][HTML] An Insight into Rational Drug Design: The Development of In-House Azole Compounds with Antimicrobial Activity
Antimicrobial resistance poses a major threat to global health as the number of efficient
antimicrobials decreases and the number of resistant pathogens rises. Our research group …
antimicrobials decreases and the number of resistant pathogens rises. Our research group …
Design, synthesis and antifungal activity evaluation of new thiazolin-4-ones as potential lanosterol 14α-demethylase inhibitors
Twenty-three thiazolin-4-ones were synthesized starting from phenylthioamide or thiourea
derivatives by condensation with α-monochloroacetic acid or ethyl α-bromoacetate, followed …
derivatives by condensation with α-monochloroacetic acid or ethyl α-bromoacetate, followed …
[PDF][PDF] Microwave assisted synthesis of 3, 5-disubstituted thiazolidine-2, 4-diones with antifungal activity. Design, synthesis, virtual and in vitro antifungal screening
Abstract Twelve thiazolidin-2, 4-diones were obtained by microwave assisted synthesis. All
the synthesized compounds were physicochemically characterized and the IR (infrared …
the synthesized compounds were physicochemically characterized and the IR (infrared …
3, 5-Disubstituted thiazolidine-2, 4-diones: Design, microwave-assisted synthesis, antifungal activity, and ADMET screening
A series of 12 new thiazolidine-2, 4-dione derivatives were obtained by microwave-assisted
synthesis. All compounds were physicochemically characterized by quantitative elemental …
synthesis. All compounds were physicochemically characterized by quantitative elemental …
Synthetic aspects and Biological Studies of some Heterocycles.
D Gandhi, P Kalal, S Agarwal - Chemistry & Biology Interface, 2017 - search.ebscohost.com
Heterocyclic chemistry is a key branch of chemistry dealing with synthesis, properties and
applications of heterocycles. Heterocycles have enormous potential as the most promising …
applications of heterocycles. Heterocycles have enormous potential as the most promising …
MgO NPs Catalyzed Eco‐Friendly Reaction: A Highly Effective and Green Approach for the Multicomponent One‐Pot Synthesis of Polysubstituted Pyridines Using 2 …
D Gandhi, S Agarwal - Journal of Heterocyclic Chemistry, 2018 - Wiley Online Library
A one‐pot multicomponent green and environmentally friendly synthesis of 5‐amino‐3‐
benzothiazol‐2‐yl‐7‐(phenyl)‐2‐phenyl‐2, 3‐dihydro‐thiazolo [4, 5‐b] pyridine‐6 …
benzothiazol‐2‐yl‐7‐(phenyl)‐2‐phenyl‐2, 3‐dihydro‐thiazolo [4, 5‐b] pyridine‐6 …
Efficient and Chemoselective Procedure for Conversion of Rhodanine Derivatives into 1, 3‐Thiazolidine‐2, 4‐diones via 1, 3‐Dipolar Cycloaddition Reaction and …
Herein, we report a chemoselective 1, 3‐dipolar cycloaddition reaction between 5‐
alkylidene‐or 5‐arylidene rhodanine derivatives and nitrile oxide generated in situ from …
alkylidene‐or 5‐arylidene rhodanine derivatives and nitrile oxide generated in situ from …
Regioselectivity evaluation of the (Z)-5-(4-hydroxybenzylidene)-thiazolidine-2, 4‑dione alkylation in alkaline environment
Abstract Thiazolidine-2, 4‑dione represents a key heterocyclic core in medicinal chemistry
because it has the ability to bind to a wide variety of protein targets and has been intensively …
because it has the ability to bind to a wide variety of protein targets and has been intensively …