MicroRNAs: key regulators in the central nervous system and their implication in neurological diseases

DD Cao, L Li, WY Chan - International journal of molecular sciences, 2016 - mdpi.com
MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …

MicroRNAs and synaptic plasticity—a mutual relationship

A Aksoy-Aksel, F Zampa… - … Transactions of the …, 2014 - royalsocietypublishing.org
MicroRNAs (miRNAs) are rapidly emerging as central regulators of gene expression in the
postnatal mammalian brain. Initial studies mostly focused on the function of specific miRNAs …

Activity-dependent spatially localized miRNA maturation in neuronal dendrites

S Sambandan, G Akbalik, L Kochen, J Rinne… - Science, 2017 - science.org
MicroRNAs (miRNAs) regulate gene expression by binding to target messenger RNAs
(mRNAs) and preventing their translation. In general, the number of potential mRNA targets …

Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury

Y Chen, Z Tian, L He, C Liu, N Wang, L Rong… - Stem cell research & …, 2021 - Springer
Background Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have
shown great potential in spinal cord injury (SCI) treatment. This research was designed to …

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

R El Fatimy, S Li, Z Chen, T Mushannen… - Acta …, 2018 - Springer
MicroRNAs (miRNA) regulate fundamental biological processes, including neuronal
plasticity, stress response, and survival. Here, we describe a neuroprotective function of miR …

Microtubule‐binding protein doublecortin‐like kinase 1 (DCLK1) guides kinesin‐3‐mediated cargo transport to dendrites

J Lipka, LC Kapitein, J Jaworski… - The EMBO journal, 2016 - embopress.org
In neurons, the polarized distribution of vesicles and other cellular materials is established
through molecular motors that steer selective transport between axons and dendrites. It is …

miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer's disease

A Ansari, E Maffioletti, E Milanesi, M Marizzoni… - Neurobiology of …, 2019 - Elsevier
The identification of mechanisms associated with Alzheimer's disease (AD) development in
mild cognitive impairment (MCI) would be of great usefulness to clarify AD pathogenesis and …

Small extracellular vesicles in milk cross the blood-brain barrier in murine cerebral cortex endothelial cells and promote dendritic complexity in the hippocampus and …

F Zhou, P Ebea, E Mutai, H Wang, S Sukreet… - Frontiers in …, 2022 - frontiersin.org
Human milk contains large amounts of small extracellular vesicles (sEVs) and their
microRNA cargos, whereas infant formulas contain only trace amounts of sEVs and …

MIRNAS in astrocyte-derived exosomes as possible mediators of neuronal plasticity: supplementary issue: brain plasticity and repair

C Lafourcade, JP Ramírez, A Luarte… - Journal of …, 2016 - journals.sagepub.com
Astrocytes use gliotransmitters to modulate neuronal function and plasticity. However, the
role of small extracellular vesicles, called exosomes, in astrocyte-to-neuron signaling is …

Synaptic dysfunction in Alzheimer's disease: Aβ, tau, and epigenetic alterations

K Li, Q Wei, FF Liu, F Hu, A Xie, LQ Zhu, D Liu - Molecular neurobiology, 2018 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized in the
early stages by loss of learning and memory. However, the mechanism underlying these …