The ocular surface, coronaviruses and COVID‐19

MDP Willcox, K Walsh, JJ Nichols… - Clinical and …, 2020 - Taylor & Francis
The ocular surface has been suggested as a site of infection with Coronavirus‐2 (SARS‐
CoV‐2) responsible for the coronavirus disease‐19 (COVID‐19). This review examines the …

Herpes simplex epithelial and stromal keratitis: an epidemiologic update

AV Farooq, D Shukla - Survey of ophthalmology, 2012 - Elsevier
Herpes simplex virus (HSV) is associated with a variety of ocular diseases, including
epithelial and stromal keratitis. HSV can cause stromal opacification and is believed to be …

Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective

E Ramelyte, A Tastanova, Z Balázs, D Ignatova… - Cancer cell, 2021 - cell.com
Talimogene laherparepvec (T-VEC) is a genetically modified herpes simplex 1 virus (HSV-1)
approved for cancer therapy. We investigate its effect on the clinical, histological, single-cell …

Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry

J Akhtar, D Shukla - The FEBS journal, 2009 - Wiley Online Library
Herpes simplex virus type‐1 and type‐2 are highly prevalent human pathogens causing life‐
long infections. The process of infection begins when the virions bind heparan sulfate …

Herpes simplex virus infects most cell types in vitro: clues to its success

GA Karasneh, D Shukla - Virology journal, 2011 - Springer
Herpes simplex virus (HSV) type-1 and type-2 have evolved numerous strategies to infect a
wide range of hosts and cell types. The result is a very successful prevalence of the virus in …

Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1

P Di Giovine, EC Settembre, AK Bhargava… - PLoS …, 2011 - journals.plos.org
Binding of herpes simplex virus (HSV) glycoprotein D (gD) to a cell surface receptor is
required to trigger membrane fusion during entry into host cells. Nectin-1 is a cell adhesion …

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea

L Koujah, RK Suryawanshi, D Shukla - Cellular and molecular life …, 2019 - Springer
Herpes simplex virus type-1 (HSV-1) is a ubiquitous pathogen that infects a large majority of
the human population worldwide. It is also a leading cause of infection-related blindness in …

Update on Herpes simplex keratitis management

D Sibley, DFP Larkin - Eye, 2020 - nature.com
Herpes simplex keratitis (HSK) is a common, potentially blinding condition characterised by
recurrent infections of the cornea, seen by both general ophthalmologists and corneal …

In the eye of the storm: SARS-CoV-2 infection and replication at the ocular surface?

L Armstrong, J Collin, I Mostafa, R Queen… - Stem Cells …, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in December
2019 and spread quickly causing the coronavirus disease 2019 (COVID-19) pandemic …

Oligomeric proanthocyanidins from Rumex acetosa L. inhibit the attachment of herpes simplex virus type-1

K Gescher, A Hensel, W Hafezi, A Derksen, J Kühn - Antiviral research, 2011 - Elsevier
The polyphenole-enriched acetone–water extract R2 from the aerial parts of Rumex acetosa
L. containing high amounts of oligomeric and polymeric proanthocyanidins and flavonoids …