Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …
Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies
Resilience in the face of major life stressors is changeable over time and with experience.
Accordingly, differing sets of neurobiological factors may contribute to an adaptive stress …
Accordingly, differing sets of neurobiological factors may contribute to an adaptive stress …
PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry
Although approximately 90% of the US population will experience a traumatic event within
their lifetime, only a fraction of those traumatized individuals will develop posttraumatic …
their lifetime, only a fraction of those traumatized individuals will develop posttraumatic …
Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure
Considerable racial/ethnic disparities persist in exposure to life stressors and
socioeconomic resources that can directly affect threat neurocircuitry, particularly the …
socioeconomic resources that can directly affect threat neurocircuitry, particularly the …
Brain-based biotypes of psychiatric vulnerability in the acute aftermath of trauma
Objective: Major negative life events, such as trauma exposure, can play a key role in
igniting or exacerbating psychopathology. However, few disorders are diagnosed with …
igniting or exacerbating psychopathology. However, few disorders are diagnosed with …
Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the …
NG Harnett, SJH van Rooij, TD Ely… - …, 2021 - nature.com
Neurobiological markers of future susceptibility to posttraumatic stress disorder (PTSD) may
facilitate identification of vulnerable individuals in the early aftermath of trauma. Variability in …
facilitate identification of vulnerable individuals in the early aftermath of trauma. Variability in …
Defining the r factor for post-trauma resilience and its neural predictors
Although resilience is a dynamic process of recovery after trauma, in most studies it is
conceptualized as the absence of specific psychopathology following trauma. Here, using …
conceptualized as the absence of specific psychopathology following trauma. Here, using …
Increased activation of the fear neurocircuitry in children exposed to violence
SJH van Rooij, RD Smith, AF Stenson… - Depression and …, 2020 - Wiley Online Library
Most studies investigating the effect of childhood trauma on the brain are retrospective and
mainly focus on maltreatment, whereas different types of trauma exposure such as growing …
mainly focus on maltreatment, whereas different types of trauma exposure such as growing …
Impaired inhibition as an intermediate phenotype for PTSD risk and treatment response
SJH van Rooij, T Jovanovic - Progress in Neuro-Psychopharmacology and …, 2019 - Elsevier
Inhibition of fear involves learning and then appropriately responding to safety signals, and
has been shown to be impaired in PTSD patients. Response inhibition refers to cognitive …
has been shown to be impaired in PTSD patients. Response inhibition refers to cognitive …
[HTML][HTML] Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms
EL Belleau, LE Ehret, JL Hanson, KJ Brasel… - Neurobiology of …, 2020 - Elsevier
Understanding neural mechanisms that confer risk for posttraumatic stress disorder (PTSD)
is critical for earlier intervention, yet longitudinal work has been sparse. The amygdala is …
is critical for earlier intervention, yet longitudinal work has been sparse. The amygdala is …