During the last two decades, an increasing number of reports have pointed out that the
immunogenicity of polyethylene glycol (PEG) may trigger accelerated blood clearance …

Liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma are global health
problems accounting for approximately 800 million cases and over 2 million deaths per year …

Lipid nanoparticles (LNPs) are the leading nonviral technologies for the delivery of
exogenous RNA to target cells in vivo. As systemic delivery platforms, these technologies …

Every day, megakaryocytes produce billions of platelets that circulate for several days and
eventually are cleared by the liver. The exact removal mechanism, however, remains …

The porosity of liver sinusoidal endothelial cells (LSEC) ensures bidirectional passive
transport of lipoproteins, drugs and solutes between the liver capillaries and the liver …

Glomerular endothelial cell (GEnC) fenestrations are a critical component of the glomerular
filtration barrier. Their unique nondiaphragmed structure is key to their function in glomerular …

Background Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called
fenestrations, participating in the bidirectional transport between the vascular system and …

The fenestrae of liver sinusoidal endothelial cells (LSECs) allow passive transport of solutes,
macromolecules, and particulate material between the sinusoidal lumen and the liver …

The liver is the largest internal organ in the human body with largest mass of glandular
tissue. Modeling the liver has been challenging due to its variety of major functions …

Healthy liver sinusoidal endothelial cells (LSECs) maintain liver homeostasis, while LSEC
dysfunction was suggested to coincide with defenestration. Here, we have revisited the …