Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

The antioxidant activity of prenylflavonoids

CMM Santos, AMS Silva - Molecules, 2020 - mdpi.com
Prenylated flavonoids combine the flavonoid moiety and the lipophilic prenyl side-chain. A
great number of derivatives belonging to the class of chalcones, flavones, flavanones …

Synthetic and natural iron chelators: therapeutic potential and clinical use

HC Hatcher, RN Singh, FM Torti… - Future medicinal …, 2009 - Taylor & Francis
Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many
years, the standard for this purpose has been deferoxamine. Recently, considerable …

Iron-binding and anti-Fenton properties of baicalein and baicalin

CA Perez, Y Wei, M Guo - Journal of inorganic biochemistry, 2009 - Elsevier
Baicalein and baicalin, the major bioactive compounds found in the Chinese herb
Scutellaria baicalensis, have been shown to be effective against cancer, bacterial infections …

Two new ternary complexes of copper (II) with tetracycline or doxycycline and 1, 10-phenanthroline and their potential as antitumoral: cytotoxicity and DNA cleavage

PP Silva, W Guerra, JN Silveira, AMC Ferreira… - Inorganic …, 2011 - ACS Publications
This paper reports on the synthesis and characterization of two new ternary copper (II)
complexes:[Cu (doxycycline)(1, 10-phenanthroline)(H2O)(ClO4)](ClO4)(1) and [Cu …

Role of iron in aging related diseases

WJ Chen, GP Kung, JP Gnana-Prakasam - Antioxidants, 2022 - mdpi.com
Iron progressively accumulates with age and can be further exacerbated by dietary iron
intake, genetic factors, and repeated blood transfusions. While iron plays a vital role in …

An update of prenylated phenolics: Food sources, chemistry and health benefits

SK Chang, Y Jiang, B Yang - Trends in Food Science & Technology, 2021 - Elsevier
Background Prenylated phenolics, a type of important bioactive compounds, present with
prenyl group on the phenolic skeleton. Prenylated flavonoids, stilbenoids, courmarins and …

Ferrosenescence: the iron age of neurodegeneration?

A Sfera, K Bullock, A Price, L Inderias… - Mechanisms of ageing and …, 2018 - Elsevier
Aging has been associated with iron retention in many cell types, including the neurons,
promoting neurodegeneration by ferroptosis. Excess intracellular iron accelerates aging by …

Synthesis, characterization, spectroscopic and antioxidation studies of Cu (II)–morin complex

QK Panhwar, S Memon, MI Bhanger - Journal of molecular structure, 2010 - Elsevier
Complex formation between copper (II) sulfate and morin (3, 5, 7, 2′, 4′-
pentahydroxyflavone) have been studied in methanol. Structure of the complex was …

Nickel (II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-κB transactivation

HB Shawish, WY Wong, YL Wong, SW Loh, CY Looi… - PloS one, 2014 - journals.plos.org
Background The biological properties of thiosemicarbazone have been widely reported. The
incorporation of some transition metals such as Fe, Ni and Cu to thiosemicarbazone …