Abstract Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic
potential. Since its identification, various cancer-promoting roles of MDM2 such as growth …

A cardinal feature that distinguishes clinically high-risk neuroblastoma from low-risk tumors
is telomere maintenance. Specifically, neuroblastoma tumors with either active telomerase …

Patients with high-risk neuroblastoma generally present with widely metastatic disease and
often relapse despite intensive therapy. As most studies to date focused on diagnosis …

Aim The study was designed to evaluate molecular alterations, relevant to the prognosis and
personalized therapy of salivary gland cancers (SGCs). Materials and methods DNA was …

Background Gene fusions are important cancer drivers in pediatric cancer and their accurate
detection is essential for diagnosis and treatment. Clinical decision-making requires high …

Childhood cancer is considered rare, corresponding to~ 3% of all malignant neoplasms in
the human population. The World Health Organization (WHO) reports a universal …

In recent years, much research has been carried out to identify the biological and genetic
characteristics of the neuroblastoma (NB) tumor in order to precisely define the prognostic …

Simple Summary Neuroblastoma (NB) is the most common extra-cranial solid paediatric
cancer and is responsible for 15% of childhood cancer deaths. Patients with NB are …

Background Childhood cancer is still a leading cause of death around the world. To improve
outcomes, there is an urgent need for tailored treatment. The systematic evaluation of …

In neuroblastoma, MYCN amplification and 11q-deletion are important, although incomplete,
markers of high-risk disease. It is therefore relevant to characterize additional alterations that …