Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

Eukaryotic genomes are folded into loops and topologically associating domains, which
contribute to chromatin structure, gene regulation, and gene recombination. These …

Structural maintenance of chromosomes (SMC) complexes organize genome topology in all
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …

Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …

As a ring-shaped adenosine triphosphatase (ATPase) machine, cohesin organizes the
eukaryotic genome by extruding DNA loops and mediates sister chromatid cohesion by …

Condensins are large protein complexes that play a central role in chromosome
organization and segregation in the three domains of life. They display highly characteristic …

Condensin plays crucial roles in chromosome organization and compaction, but the
mechanistic basis for its functions remains obscure. We used single-molecule imaging to …

Analyses of protein complexes are facilitated by methods that enable the generation of
recombinant complexes via coexpression of their subunits from multigene DNA constructs …

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart
from its role in mediating sister chromatid cohesion, it is also important for DNA double …