MJ Goumans, A Zwijsen… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
It is well established that control of vascular morphogenesis and homeostasis is regulated by vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), Delta-like 4 …
NF Voelkel, J Gomez-Arroyo - American journal of respiratory cell …, 2014 - atsjournals.org
Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis leading to lung vessel obliteration. PAH is widely considered a proangiogenic disease; …
SH Vitali, G Hansmann, C Rose… - Pulmonary …, 2014 - journals.sagepub.com
The combination of a vascular endothelial growth factor receptor antagonist, Sugen 5416 (SU5416), and chronic hypoxia is known to cause pronounced pulmonary hypertension …
R Tamosiuniene, O Manouvakhova… - Circulation …, 2018 - Am Heart Assoc
Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …
JP Dignam, TE Scott, BK Kemp‐Harper… - British Journal of …, 2022 - Wiley Online Library
Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease due to the development of right ventricular (RV) failure. At present, no treatments targeted at …
S Sakao, NF Voelkel, K Tatsumi - European respiratory review, 2014 - Eur Respiratory Soc
The loss of pulmonary vessels has been shown to be related to the severity of pulmonary hypertension in patients with chronic obstructive pulmonary disease (COPD). The severity of …
RM Tuder, E Stacher, J Robinson… - Clinics in chest …, 2013 - chestmed.theclinics.com
The last 2 generations of physicians and researchers in pulmonary hypertension (PH) have undergone their training, performed investigations, and practiced without a thorough …
SS Pullamsetti, R Savai, W Seeger… - American journal of …, 2017 - atsjournals.org
Pulmonary arterial hypertension (PAH) has been frequently compared with a type of malignant disease and has an incredible number of pathogenic mechanisms similar to …