Bronchiectasis—a clinical review

AE O'Donnell - New England Journal of Medicine, 2022 - Mass Medical Soc
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Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations

S Aliberti, PC Goeminne, AE O'Donnell… - The Lancet …, 2022 - thelancet.com
Bronchiectasis refers to both a clinical disease and a radiological appearance that has
multiple causes and can be associated with a range of conditions. Disease heterogeneity …

Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC)

JD Chalmers, E Polverino, ML Crichton… - The Lancet …, 2023 - thelancet.com
Background Bronchiectasis is a heterogeneous, neglected disease with few multicentre
studies exploring the causes, severity, microbiology, and treatment of the disease across …

European Respiratory Society guidelines for the management of adult bronchiectasis

E Polverino, PC Goeminne… - European …, 2017 - Eur Respiratory Soc
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent
exacerbations in many patients. There have been no previous international guidelines. The …

European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis

AB Chang, R Fortescue, K Grimwood… - European …, 2021 - Eur Respiratory Soc
There is increasing awareness of bronchiectasis in children and adolescents, a chronic
pulmonary disorder associated with poor quality of life for the child/adolescent and their …

Integrative microbiomics in bronchiectasis exacerbations

M Mac Aogain, JK Narayana, PY Tiew, NABM Ali… - Nature medicine, 2021 - nature.com
Bronchiectasis, a progressive chronic airway disease, is characterized by microbial
colonization and infection. We present an approach to the multi-biome that integrates …

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity

PA Flume, JD Chalmers, KN Olivier - The Lancet, 2018 - thelancet.com
Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study

HR Keir, A Shoemark, AJ Dicker, L Perea… - The lancet Respiratory …, 2021 - thelancet.com
Background Bronchiectasis is predominantly a neutrophilic inflammatory disease. There are
no established therapies that directly target neutrophilic inflammation because little is …

[HTML][HTML] Phase 2 trial of the DPP-1 inhibitor brensocatib in bronchiectasis

JD Chalmers, CS Haworth, ML Metersky… - … England Journal of …, 2020 - Mass Medical Soc
Background Patients with bronchiectasis have frequent exacerbations that are thought to be
related to neutrophilic inflammation. The activity and quantity of neutrophil serine proteases …

Bronchiectasis

JD Chalmers, AB Chang, SH Chotirmall… - Nature reviews Disease …, 2018 - nature.com
Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …