The roles of structural dynamics in the cellular functions of RNAs
RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
2′-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states
O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …
important biological roles through mechanisms that are not entirely understood. There is …
RNA conformational propensities determine cellular activity
Cellular processes are the product of interactions between biomolecules, which associate to
form biologically active complexes. These interactions are mediated by intermolecular …
form biologically active complexes. These interactions are mediated by intermolecular …
Structural and computational studies of HIV-1 RNA
L Levintov, H Vashisth - RNA biology, 2024 - Taylor & Francis
Viruses remain a global threat to animals, plants, and humans. The type 1 human
immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …
immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …
[HTML][HTML] Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction
Biomolecules form dynamic ensembles of many inter-converting conformations which are
key for understanding how they fold and function. However, determining ensembles is …
key for understanding how they fold and function. However, determining ensembles is …
Exposing hidden high-affinity RNA conformational states
NI Orlovsky, HM Al-Hashimi, TG Oas - Journal of the American …, 2019 - ACS Publications
RNA recognition frequently results in conformational changes that optimize intermolecular
binding. As a consequence, the overall binding affinity of RNA to its binding partners …
binding. As a consequence, the overall binding affinity of RNA to its binding partners …
3D structure stability of the HIV-1 TAR RNA in ion solutions: A coarse-grained model study
As an extremely common structural motif, RNA hairpins with bulge loops [eg, the human
immunodeficiency virus type 1 (HIV-1) transactivation response (TAR) RNA] can play …
immunodeficiency virus type 1 (HIV-1) transactivation response (TAR) RNA] can play …
Probing RNA structures and interactions using fluorescence lifetime analyses
J Zhang - RNA Structure and Dynamics, 2022 - Springer
Structural analyses of large, complex noncoding RNAs continue to lag behind their rapid
discovery and functional descriptions. Site-specifically incorporated, minimally invasive …
discovery and functional descriptions. Site-specifically incorporated, minimally invasive …
RNA conformational propensities determine cellular activity
Cellular processes are the product of interactions between biomolecules, which associate to
form biologically active complexes. These interactions are mediated by intermolecular …
form biologically active complexes. These interactions are mediated by intermolecular …
RNA Conformational Ensembles from NMR Residual Dipolar Couplings
H SHId, HM AL-HASHIMI - Residual Dipolar Couplings …, 2024 - books.google.com
RNAs are recognized as major players in biology and their biomedical importance is
increasing rapidly1–5 as drug-targets and therapeutics for treating infectious diseases …
increasing rapidly1–5 as drug-targets and therapeutics for treating infectious diseases …