O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays important biological roles through mechanisms that are not entirely understood. There is …
Cellular processes are the product of interactions between biomolecules, which associate to form biologically active complexes. These interactions are mediated by intermolecular …
Viruses remain a global threat to animals, plants, and humans. The type 1 human immunodeficiency virus (HIV-1) is a member of the retrovirus family and carries an RNA …
Biomolecules form dynamic ensembles of many inter-converting conformations which are key for understanding how they fold and function. However, determining ensembles is …
NI Orlovsky, HM Al-Hashimi, TG Oas - Journal of the American …, 2019 - ACS Publications
RNA recognition frequently results in conformational changes that optimize intermolecular binding. As a consequence, the overall binding affinity of RNA to its binding partners …
BG Zhang, HH Qiu, J Jiang, J Liu, YZ Shi - The Journal of Chemical …, 2019 - pubs.aip.org
As an extremely common structural motif, RNA hairpins with bulge loops [eg, the human immunodeficiency virus type 1 (HIV-1) transactivation response (TAR) RNA] can play …
J Zhang - RNA Structure and Dynamics, 2022 - Springer
Structural analyses of large, complex noncoding RNAs continue to lag behind their rapid discovery and functional descriptions. Site-specifically incorporated, minimally invasive …
Cellular processes are the product of interactions between biomolecules, which associate to form biologically active complexes. These interactions are mediated by intermolecular …
RNAs are recognized as major players in biology and their biomedical importance is increasing rapidly1–5 as drug-targets and therapeutics for treating infectious diseases …