Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …

The regulation of cerebrovascular permeability is critical for normal brain homeostasis, and
the “breakdown” of the blood-brain barrier (BBB) is associated with the development of …

Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is
markedly limited owing to concerns about hemorrhagic complications and the requirement …

Blood–brain barrier (BBB) disruption, mediated through matrix metalloproteinases (MMPs)
and other mechanisms, is a critical event during ischemic stroke. Tissue plasminogen …

Although neuronal stress circuits have been identified, little is known about the mechanisms
that underlie the stress-induced neuronal plasticity leading to fear and anxiety. Here we …

To get insight into the mechanisms that may lead to progression of temporal lobe epilepsy,
we investigated gene expression during epileptogenesis in the rat. RNA was obtained from …

Point mutations cause members of the serine protease inhibitor (serpin) superfamily to
undergo a novel conformational transition, forming ordered polymers. These polymers …

Tissue plasminogen activator (tPA), a fibrin specific activator for the conversion of
plasminogen to plasmin, stimulates thrombolysis and rescues ischemic brain by restoring …

The low‐density lipoprotein (LDL) receptor related protein (LRP1 or LRP) is a large
endocytic receptor widely expressed in several tissues and known to play roles in areas as …