Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …

The study of the basic physiology of the neural precursors generated during brain
development is driven by two inextricably linked goals. First, such knowledge is instrumental …

Background Huntington's disease (HD) is a neurodegenerative disorder caused by the
expansion of the CAG repeat in the huntingtin (HTT) gene. When the number of CAG …

Expansion of a polyglutamine sequence in the N terminus of huntingtin is the gain-of-
function event that causes Huntington's disease. This mutation affects primarily the medium …

Glioblastomas, the most frequent and malignant of primary brain tumors, have a very poor
prognosis 1. Gene therapy of glioblastomas is limited by the short survival of viral vectors …

Gene expression studies conducted with mouse models of Huntington's disease (HD) have
revealed profound modifications in gene transcription. However, the complexity of in vivo …

Epidermal Growth Factor (EGF)-responsive stem cells isolated from the developing central
nervous system (CNS) can be expanded exponentially in culture while retaining the ability to …

Immortalized multipotent neural stem and progenitor cells have emerged as a highly
convenient source of tissue for genetic manipulation and ex vivo gene transfer to the CNS …

In order to assess the potential of embryonic stem cells to undergo neuronal differentiationin
vivo, totipotent stem cells from mouse blastocysts (D3 and E14TG2a; previously expanded in …

Different cerebellar phenotypes are generated according to a precise spatiotemporal
schedule, in which projection neurons precede local interneurons. Glutamatergic neurons …