[HTML][HTML] Orphan G protein-coupled receptors: The role in CNS disorders
There are various types of receptors in the central nervous system (CNS). G protein-coupled
receptors (GPCRs) have the highest expression with a wide range of physiological …
receptors (GPCRs) have the highest expression with a wide range of physiological …
The supply chain of human pancreatic β cell lines
R Scharfmann, W Staels… - The Journal of clinical …, 2019 - Am Soc Clin Investig
Patients with type 1 or type 2 diabetes have an insufficiency in their functional β cell mass.
To advance diabetes treatment and to work toward a cure, a better understanding of how to …
To advance diabetes treatment and to work toward a cure, a better understanding of how to …
In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells
The progression of Alzheimer's disease is causatively linked to the accumulation of amyloid-
β aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the …
β aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the …
Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling …
Oxidative stress-induced neuron apoptosis plays a crucial role in the early brain injury (EBI)
after subarachnoid hemorrhage (SAH). Kisspeptin has been reported as antioxidant to …
after subarachnoid hemorrhage (SAH). Kisspeptin has been reported as antioxidant to …
Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro
The neuropathological substrate of dementia with Lewy bodies (DLB) is defined by the
inextricable cross-seeding accretion of amyloid-β (Aβ) and α-synuclein (α-syn)-laden …
inextricable cross-seeding accretion of amyloid-β (Aβ) and α-synuclein (α-syn)-laden …
KISS1 in metastatic cancer research and treatment: potential and paradoxes
The significance of KISS1 goes beyond its original discovery as a metastasis suppressor. Its
function as a neuropeptide involved in diverse physiologic processes is more well studied …
function as a neuropeptide involved in diverse physiologic processes is more well studied …
Native Mass Spectrometry-Centric Approaches Revealed That Neuropeptides Frequently Interact with Amyloid-β
D Wang, G Wang, X Wang, Z Ren… - ACS Chemical …, 2024 - ACS Publications
Amyloid-β (Aβ) aggregates are recognized as initiators of Alzheimer's disease, and their
interaction with the nervous system contributes to the progression of neurodegeneration …
interaction with the nervous system contributes to the progression of neurodegeneration …
Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1–42 in mice novel object and object location recognition tasks
JH Jiang, Z He, YL Peng, WD Jin, Z Wang… - Neurobiology of learning …, 2015 - Elsevier
Kisspeptin (KP), the endogenous ligand of GPR54, is a recently discovered neuropeptide
shown to be involved in regulating reproductive system, anxiety-related behavior …
shown to be involved in regulating reproductive system, anxiety-related behavior …
A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the progression and treatment of Alzheimer's disease
The amyloid-β peptide (Aβ) has been associated with Alzheimer's disease (AD) for decades.
The original amyloid cascade hypothesis declared that the insoluble extracellular plaques …
The original amyloid cascade hypothesis declared that the insoluble extracellular plaques …
[HTML][HTML] Kisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner
The hypothalamic neurohormone kisspeptin-10 (KP-10) was inherently implicated in
cholinergic pathologies when aberrant fluctuations of expression patterns and receptor …
cholinergic pathologies when aberrant fluctuations of expression patterns and receptor …