Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Molecular interactions between the active pharmaceutical ingredient and polymer have
potentially substantial impacts on the physical stability of amorphous solid dispersions …

In recent years it is shown that mechanochemical strategies can be beneficial in directed
conversions of organic compounds. Finding new reactions proved difficult, and due to the …

Common energy-intensive processes applied in oral solid dosage development, such as
milling, sieving, blending, compaction, etc. generate particles with surface and bulk crystal …

Quantifying low-level components in solid-state analysis presents a significant challenge for
most thermal, diffractometric, vibrational, and spectroscopic techniques. In pharmaceutical …

The structural investigation of amorphous pharmaceuticals is of paramount importance in
comprehending their physicochemical stability. However, it has remained a relatively …

Solid-state NMR has been increasingly recognized as a high-resolution and versatile
spectroscopic tool to characterize drug substances and products. However, the analysis of …

High-resolution solid-state analysis of multicomponent molecular systems, eg,
pharmaceutical formulations, is a great challenge. Solid-state nuclear magnetic resonance …

Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs),
notable for its ability to enable the production of ASDs containing pharmaceuticals with …