The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Aim: This review describes molecular and functional properties of the following Cl–channels:
the ClC family of voltage‐dependent Cl–channels, the cAMP‐activated transmembrane …

The volume-regulated anion channel (VRAC) is activated when a cell swells, and it plays a
central role in maintaining cell volume in response to osmotic challenges. SWELL1 …

Volume-regulated anion channels are activated in response to hypotonic stress. These
channels are composed of closely related paralogues of the leucine-rich repeat-containing …

We have studied activation by phorbol derivatives of TRPV4 channels, the human VRL-2,
and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

The volume-regulated anion channel (VRAC), also known as the volume-sensitive
outwardly rectifying (VSOR) anion channel or the volume-sensitive organic osmolyte/anion …

The swelling-activated anion channel VRAC has fascinated and frustrated physiologists
since it was first described in 1988. Multiple laboratories have defined VRAC's biophysical …

LRRC8 family proteins on the plasma membrane play a critical role in cellular
osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent …

Anion transport proteins in mammalian cells participate in a wide variety of cell and
intracellular organelle functions, including regulation of electrical activity, pH, volume, and …