Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Autophagy is a lysosomal protein degradation system that eliminates cytoplasmic
components such as protein aggregates, damaged organelles, and even invading …

Acute kidney injury (AKI) is one of the main conditions responsible for chronic kidney
disease (CKD), including end-stage renal disease (ESRD) as a long-term complication …

Abstract p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While
involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the …

Aims Cyclophosphamide is an alkylating agent with vast arrays of therapeutic activity.
Currently, its medical use is limited due to its numerous adverse events, including …

Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of
tissue inflammation, contraction and scar formation. Here we identify a multipotent fibroblast …

Renal ischemia–reperfusion injury (IRI) is less extensive in females than males in both
animals and humans; however, this protection diminishes after menopause, suggesting that …

Chronic allograft dysfunction with progressive fibrosis of unknown cause remains a major
issue after kidney transplantation, characterized by ischemia-reperfusion injury (IRI). One …

Chronic kidney disease (CKD) is a progressive condition of kidney dysfunction due to
diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are …

Purpose The serine protease inhibitor clade E member 1 (SERPINE1) has been studied as
a potential biomarker in a variety of cancers, but poorly studied in gastric cancer (GC). The …