Tumor-associated macrophages are a major constituent of malignant tumors and are known
to stimulate key steps in tumor progression. In our review in this journal in 2006, we …

Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend
against pathogens; however, their infiltration into tumors has been associated with adverse …

Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system.
Here we review emerging key properties of different forms of macrophage activation and …

Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular
agents of innate immunity. Here, we have examined the inflammatory response in mice with …

The role of macrophages in tumour growth and development is complex and multifaceted.
Whilst there is limited evidence that tumour‐associated macrophages (TAMs) can be directly …

The mechanisms responsible for recruiting monocytes from the bloodstream into solid
tumors are now well characterized. However, recent evidence has shown that these cells …

Cell adaptation to hypoxia (Hyp) requires activation of transcriptional programs that
coordinate expression of genes involved in oxygen delivery (via angiogenesis) and …

Recent studies consistently support a hypoxia response in the adipose tissue in obese
animals. The observations have led to the formation of an exciting concept, adipose tissue …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

It is now recognized that the host microenvironment undergoes extensive change during the
evolution and progression of cancer. This involves the generation of cancer‐associated …