The role of inhibitory circuits in hippocampal memory processing

L Topolnik, S Tamboli - Nature Reviews Neuroscience, 2022 - nature.com
GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

Neuronal circuitry for recognition memory of object and place in rodent models

OY Chao, S Nikolaus, YM Yang, JP Huston - … & Biobehavioral Reviews, 2022 - Elsevier
Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …

Prefrontal somatostatin interneurons encode fear memory

KA Cummings, RL Clem - Nature neuroscience, 2020 - nature.com
Theories stipulate that memories are encoded within networks of cortical projection neurons.
Conversely, GABAergic interneurons are thought to function primarily to inhibit projection …

Cortical disinhibitory circuits: cell types, connectivity and function

K Kullander, L Topolnik - Trends in Neurosciences, 2021 - cell.com
The concept of a dynamic excitation/inhibition balance tuned by circuit disinhibition, which
can shape information flow during complex behavioral tasks, has arisen as an important and …

Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance

EV Varela, G Etter, S Williams - Neurobiology of disease, 2019 - Elsevier
The interplay between excitatory and inhibitory circuits underlies the brain's processes and
their dysregulation has been linked to cognitive decline, psychiatric disorders and epilepsy …

[HTML][HTML] Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

S Mikulovic, CE Restrepo, S Siwani, P Bauer… - Nature …, 2018 - nature.com
Dorsal and ventral hippocampus regions exert cognition and emotion-related functions,
respectively. Since both regions display rhythmic activity, specific neural oscillatory …

Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas

JA Matta, S Gu, WB Davini, DS Bredt - Science, 2021 - science.org
BACKGROUND One hundred years ago, experiments on beating frog hearts identified
acetylcholine (ACh) as the seminal neurotransmitter. Sixty years later, fractionation of the eel …

α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity

AC Letsinger, Z Gu, JL Yakel - Trends in neurosciences, 2022 - cell.com
Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh)
to coordinate neuronal circuit activity while simultaneously influencing the function of non …

Hippocampal somatostatin interneurons, long-term synaptic plasticity and memory

E Honoré, A Khlaifia, A Bosson… - Frontiers in neural circuits, 2021 - frontiersin.org
A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons.
These complex inhibitory interconnections largely contribute to the tight modulation of …

Brainstem nucleus incertus controls contextual memory formation

A Szőnyi, KE Sos, R Nyilas, D Schlingloff, A Domonkos… - Science, 2019 - science.org
INTRODUCTION Associative learning is essential for survival, and the mammalian
hippocampal neurocircuitry has been shown to play a central role in the formation of specific …