The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Activation of ferroptosis, a recently described mechanism of regulated cell death,
dramatically inhibits growth of ovarian cancer cells. Given the importance of lipid metabolism …

Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

Summary p53 is a frequent target for mutation in human tumors, and mutant p53 proteins
can actively contribute to tumorigenesis. We employed a three-dimensional culture model in …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

The tumor suppressor p53 functions predominantly as a transcription factor by activating and
downregulating gene expression, leading to cell cycle arrest or apoptosis. p53 was shown to …

The p53 protein regulates the transcription of many different genes in response to a wide
variety of stress signals. Following DNA damage, p53 regulates key processes, including …

The ability to derive a whole-genome map of transcription-factor binding sites (TFBS) is
crucial for elucidating gene regulatory networks. Herein, we describe a robust approach that …