Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
R Pecori, S Di Giorgio, J Paulo Lorenzo… - Nature Reviews …, 2022 - nature.com
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
Acquisition of the L452R mutation in the ACE2-binding interface of Spike protein triggers recent massive expansion of SARS-Cov-2 variants
V Tchesnokova, H Kulasekara, L Larson… - Journal of clinical …, 2021 - Am Soc Microbiol
We report that there is a recent global expansion of numerous independent severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the …
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the …
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review
SA SeyedAlinaghi, P Mirzapour, O Dadras… - European journal of …, 2021 - Springer
Abstract Introduction Coronavirus Disease-2019 (SARS-CoV-2) started its devastating
trajectory into a global pandemic in Wuhan, China, in December 2019. Ever since, several …
trajectory into a global pandemic in Wuhan, China, in December 2019. Ever since, several …
The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness
During COVID-19 pandemic, mutations of SARS-CoV-2 produce new strains that can be
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …
more infectious or evade vaccines. Viral RNA mutations can arise from misincorporation by …
Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck
The evolutionary mechanisms by which SARS-CoV-2 viruses adapt to mammalian hosts
and, potentially, undergo antigenic evolution depend on the ways genetic variation is …
and, potentially, undergo antigenic evolution depend on the ways genetic variation is …
[PDF][PDF] Mutation rates and selection on synonymous mutations in SARS-CoV-2
The COVID-19 pandemic has seen an unprecedented response from the sequencing
community. Leveraging the sequence data from more than 140,000 SARS-CoV-2 genomes …
community. Leveraging the sequence data from more than 140,000 SARS-CoV-2 genomes …
Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks
The emergence of divergent SARS-CoV-2 lineages has raised concern that novel variants
eliciting immune escape or the ability to displace circulating lineages could emerge within …
eliciting immune escape or the ability to displace circulating lineages could emerge within …
SARS-CoV-2 one year on: evidence for ongoing viral adaptation
TP Peacock, R Penrice-Randal… - Journal of General …, 2021 - microbiologyresearch.org
SARS-CoV-2 is thought to have originated in the human population from a zoonotic spillover
event. Infection in humans results in a variety of outcomes ranging from asymptomatic cases …
event. Infection in humans results in a variety of outcomes ranging from asymptomatic cases …
[HTML][HTML] Host-directed editing of the SARS-CoV-2 genome
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has
facilitated the study of viral genome evolution over a brief period of time. This has …
facilitated the study of viral genome evolution over a brief period of time. This has …