Inflammation is an essential immune response characterized by pain, swelling, redness,
heat, and impaired function. A controlled acute inflammatory response is necessary to fight …

Aging is one of the major non-reversible risk factors for several chronic diseases, including
cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause …

Macrophages control the resolution of inflammation through the transition from a
proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence …

Aims: The response of AMP-activated protein kinase (AMPK) to oxidative stress has been
recently reported but the downstream signals of this response are largely unknown …

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the
polycystin 1 (PKD1) or polycystin 2 genes, presents with progressive development of kidney …

The mechanisms underlying the association between obesity and progressive renal disease
are not well understood. Exposure to a high-fat diet decreases levels of the cellular energy …

Highlights•Adenosine contributes to tissue integrity by modulating the immune
system.•Adenosine receptor ligands emerged for the management of inflammation.•These …

Context Ellagic acid (EA) is used in traditional medicine to treated hyperlipidaemia.
Objective This study examined if AMPK mediates the anti-steatotic effect of ellagic acid (EA) …

Abstract Objective Interleukin‐1β (IL‐1β) and tumor necrosis factor α (TNFα) stimulate
chondrocyte matrix catabolic responses, thereby compromising cartilage homeostasis in …

Atherosclerosis is a chronic inflammation of the coronary arteries. Vascular smooth muscle
cells (VSMCs) stimulated by cytokines and chemokines accelerate the inflammatory …