Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits

KJ Ressler, S Berretta, VY Bolshakov… - Nature Reviews …, 2022 - nature.com
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …

Targeting VIP and PACAP receptor signaling: new insights into designing drugs for the PACAP subfamily of receptors

J Lu, SJ Piper, P Zhao, LJ Miller, D Wootten… - International journal of …, 2022 - mdpi.com
Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and Vasoactive Intestinal Peptide
(VIP) are neuropeptides involved in a diverse array of physiological and pathological …

Why the estrous cycle matters for neuroscience

D Rocks, H Cham, M Kundakovic - Biology of sex Differences, 2022 - Springer
Background Ovarian hormone fluctuations over the rodent estrous cycle and the human
menstrual cycle are known to significantly impact brain physiology and disease risk, yet this …

Davunetide sex-dependently boosts memory in prodromal Alzheimer's disease

I Gozes, J Blatt, A Lobyntseva - Translational Psychiatry, 2024 - nature.com
Background The tauopathy inhibitor, davunetide shows sex-dependent efficacy in women
suffering from progressive supranuclear palsy. Extending these findings to prodromal …

The molecular relationship between stress and insomnia

JN Birch, WM Vanderheyden - Advanced Biology, 2022 - Wiley Online Library
The bi‐directional relationship between sleep and stress has been actively researched as
sleep disturbances and stress have become increasingly common in society. Interestingly …

Metabolomic biomarkers in anxiety disorders

E Humer, C Pieh, T Probst - International Journal of Molecular Sciences, 2020 - mdpi.com
Anxiety disorders range among the most prevalent psychiatric disorders and belong to the
leading disorders in the study of the total global burden of disease. Anxiety disorders are …

PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus

ER Velasco, A Florido, Á Flores, E Senabre… - Nature …, 2022 - nature.com
Exposure to traumatic stress can lead to fear dysregulation, which has been associated with
posttraumatic stress disorder (PTSD). Previous work showed that a polymorphism in the …

Peripheral biomarkers in DSM-5 anxiety disorders: an updated overview

M Vismara, N Girone, G Cirnigliaro, F Fasciana… - Brain Sciences, 2020 - mdpi.com
Anxiety disorders are prevalent and highly disabling mental disorders. In recent years,
intensive efforts focused on the search for potential neuroimaging, genetic, and peripheral …

The functional heterogeneity of PACAP: Stress, learning, and pathology

AK Rajbhandari, JR Barson, MR Gilmartin… - Neurobiology of learning …, 2023 - Elsevier
Pituitary adenylate cyclase-activating peptide (PACAP) is a highly conserved and widely
expressed neuropeptide that has emerged as a key regulator of multiple neural and …

Distribution of PACAP and PAC1 Receptor in the Human Eye

E Patko, E Szabo, D Toth, T Tornoczky… - Journal of Molecular …, 2022 - Springer
Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide with
widespread distribution and diverse biological functions. Several studies show that PACAP …