Methylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir,
MeHg bioaccumulates along the food chain until it is consumed by riverine populations …

In recent years neurodevelopmental problems in children have increased at a rate that
suggests lifestyle factors and chemical exposures as likely contributors. When …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Background Developmental neurotoxicity (DNT) of environmental chemicals is a serious
threat to human health. Current DNT testing guidelines propose investigations in rodents …

The pathological hallmarks of Alzheimer's disease (AD) consist of β-amyloid plaques and
neurofibrillary tangles in affected brain areas. The processes, which drive this host reaction …

The incidence of neurodegenerative disease like Parkinson's disease and Alzheimer's
disease (AD) increases dramatically with age; only a small percentage is directly related to …

Alzheimer's disease (AD) is associated with dementia, brain atrophy and the aggregation
and accumulation of a cortical amyloid-β peptide (Aβ). Chronic bacterial infections are …

Environmental exposures may influence sleep; however, the contributions of environmental
chemical pollutants to sleep health have not been systematically investigated. We …

The purpose of this review is to examine the parallels between the effects mercury
intoxication on the brain and the brain pathology found in autism spectrum disorder (ASD) …

Microglia are highly sensitive to even small changes in the brain environment, such as
invasion of non-hazardous toxicants or the presymptomatic state of diseases. However, the …