Data-independent acquisition (DIA): an emerging proteomics technology for analysis of drug-metabolizing enzymes and transporters
Data-independent acquisition (DIA) proteomics is a recently-developed global mass
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …
Quantitative proteomics in translational absorption, distribution, metabolism, and excretion and precision medicine
A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …
metabolism, and excretion (ADME) to humans is important for safe and effective drug …
Toward a consensus on applying quantitative liquid chromatography‐tandem mass spectrometry proteomics in translational pharmacology research: a white paper
Quantitative translation of information on drug absorption, disposition, receptor engagement,
and drug–drug interactions from bench to bedside requires models informed by …
and drug–drug interactions from bench to bedside requires models informed by …
Label-free absolute protein quantification with data-independent acquisition
Despite data-independent acquisition (DIA) has been increasingly used for relative protein
quantification, DIA-based label-free absolute quantification method has not been fully …
quantification, DIA-based label-free absolute quantification method has not been fully …
Quantitative proteomics and mechanistic modeling of transporter‐mediated disposition in nonalcoholic fatty liver disease
A Vildhede, E Kimoto, RM Pelis… - Clinical …, 2020 - Wiley Online Library
Understanding transporter‐mediated drug disposition and pharmacokinetics (PK) in patients
with nonalcoholic fatty liver disease (NAFLD) is critical in developing treatment options …
with nonalcoholic fatty liver disease (NAFLD) is critical in developing treatment options …
Quantification of proteins involved in drug metabolism and disposition in the human liver using label-free global proteomics
There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of
medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing) …
medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing) …
From endogenous compounds as biomarkers to plasma‐derived nanovesicles as liquid biopsy; has the golden age of translational pharmacokinetics‐absorption …
D Rodrigues, A Rowland - Clinical Pharmacology & …, 2019 - Wiley Online Library
It is now established that a drug's pharmacokinetics (PK) absorption, distribution,
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …
metabolism, excretion (ADME) and drug–drug interaction (DDI) profile can be modulated by …
Differential tissue abundance of membrane-bound drug metabolizing enzymes and transporter proteins by global proteomics
Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics of drug-metabolizing enzymes and transporters
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics is a
powerful tool for identifying and quantifying proteins in biological samples, outperforming …
powerful tool for identifying and quantifying proteins in biological samples, outperforming …
Multiple-enzyme-digestion strategy improves accuracy and sensitivity of label-and standard-free absolute quantification to a level that is achievable by analysis with …
JR Wiśniewski, C Wegler… - Journal of proteome …, 2018 - ACS Publications
Quantification of individual proteins is an essential task in understanding biological
processes. For example, determination of concentrations of proteins transporting and …
processes. For example, determination of concentrations of proteins transporting and …